CONFERENCE
PROGRAMME
CONFERENCE
PROGRAMME
2026 SESSION TOPICS
Days and timings to be confirmed.
Olivia Santoni – CEO, Bloom Regulatory Ltd
Professor Rachel Watson – Executive Director, A*STAR Skin Research Lab (A* SRL)
Dr Robert Bianchini – Chief Scientist, Dermalogica
Dr Jule Lexa Volzke – Lead of Product Creation and Development, CLR Berlin GmbH
Professor Fay Bound-Alberti – KCL AC
Michael Hoptroff – R&D Manager, Unilever
Dr Georgios Stamatas – Global Scientific Director, SGS CTS
Dr Hugo Corstjens – Consultant, Novigo+
Dr Max Brown – Senior Scientist, Proctor & Gamble
Dr Klodjan Stafa PhD EMBA – Founder, CutaneoX BioStrategies LLC
Dr Katja Bartsch – Postdoctoral Researcher, Technical University Munich, School of Medicine and Health
Mrs Clare OConner – Lead Scientist: skin healthy ageing research, Boots No 7 Company
Dr Luc Aguilar – Chief Scientific Officer for Advanced Research, L’Oréal
Andrew McDougall – Director of Insights, Beauty & Personal Care, Mintel
Nükhet Cavusoglu – Head of High-Throughput Biology and Diagnostic platform
2026 Speakers
Dr Katerina Steventon
Andrew McDougall
Dr Anjali Mahto
Dr Bob Bianchini
Dr Claudia Aguirre
Clare O'Conner
Professor Fay Bound Alberti
Dr Georgios Stamatas
Dr Holly Wilkinson
Dr Hugo Corstjens
Dr Jule Kexa Volzke
Dr Katja Bartsch
Dr Klodjan Stafa
Luc Aguilar
Dr Max Brown
Mike Hoptroff
Dr Nükhet Cavusoglu
Olivia Santoni
Professor Paul Matts
Professor Rachel Watson
Dr Katerina Steventon
Anti-Ageing Skin Care Conference Director
Biography
Dr Katerina Steventon is a skincare specialist with over 25 years’ global experience across clinical, commercial and research settings, holding an MSc in Clinical Biochemistry and a PhD in Transdermal Absorptions. She has deep expertise in skin biology, ageing and translational innovation, and runs an innovation consultancy focused on functional skincare informed by cross-cultural consumer insights.
Presentation Outline
To be confirmed.
Andrew McDougall
Director of Insights, Beauty & Personal Care, Mintel
Biography
Andrew is an innovative, competent and successful analyst and journalist, with a particular focus on the beauty sector. Since joining Mintel in 2016, he has led the team on trends, delivered projects to clients around the world, featured at the biggest and best beauty industry events, and brings over a decade of experience in the market. He has also been integral in the development of many AV initiatives, such as webinars and podcasts.
Presentation: Consumer and technology trends shaping the next era of longevity skincare
As the anti-ageing category evolves, a new paradigm is emerging; one rooted in systems biology and a deep understanding of the biological processes that underpin skin ageing. This session will explore how cutting-edge science, from the 12 Hallmarks of Ageing to cellular repair and the skin microbiome, is reshaping both product innovation and consumer expectations. We’ll examine why consumers are increasingly seeking preventative, holistic, and personalised solutions; and how technology, from advanced actives to diagnostics and delivery systems, is making these aspirations a reality. Gain actionable strategies for translating complex longevity science into relatable, credible benefits that resonate with today’s health-centric, empowered consumer, ensuring brands stand out in the next era of anti-ageing skincare.
Dr Anjali Mahto
Consultant Dermatologist, Self London
Biography
Dr Anjali Mahto is a London-based Consultant Dermatologist and founder of Self London, with specialist expertise in acne, acne scarring, cutaneous ageing and evidence-based non-surgical rejuvenation. She is the author of the international bestseller ‘The Skincare Bible’ and a leading independent clinical voice, focused on improving standards, transparency, and patient-centred, outcomes-driven care in aesthetic dermatology.
Presentation Outline
To be confirmed.
Dr Bob Bianchini
Chief Scientist, Dermalogica
Biography
Dr Robert Bianchini Vice-President Research and Innovation at Dermalogica, A Unilever Prestige Co. is a senior research scientist at Dermalogica, bringing extensive expertise in skin biology, cosmetic science and product innovation. With a strong background in applied research, Bob plays a key role in advancing Dermalogica’s evidence-based approach to skincare, supporting the development of high-performance formulations grounded in robust scientific understanding.
His work focuses on skin physiology, barrier function and the interaction between formulations and the skin, helping translate complex biological processes into practical, effective skincare solutions. Bob collaborates closely with cross-functional teams across research, formulation, testing and marketing to ensure scientific insights are embedded throughout the product development lifecycle.
At Dermalogica, he contributes to research strategy, data interpretation and technical validation, supporting claims substantiation and innovation aligned with both consumer needs and regulatory expectations. He is particularly experienced in bridging laboratory research with real-world application, ensuring that science-led innovation delivers tangible benefits for skin health.
Dr Bianchini is also an engaging industry speaker, valued for his ability to communicate complex skin science clearly and credibly to professional and commercial audiences.
Presentation: Bacterial Exosome System Combined with Micro-Injury Treatments for Enhanced Skin Rejuvenation: A Systems Biology Approach
Aging skin is characterised by a decline in cellular communication, skin imperfections and regenerative capacity, manifesting as fine lines, wrinkles, sagging, color variation and reduced firmness. Dermalogica PRO Exo Booster system is a novel, non-human derived exosome system which employs a systems biology-based approach to skin health. Utilising 10 billion Lactobacillus exosomes per treatment in an Omega 3-based delivery vehicle, it significantly enhances intercellular communication and rejuvenation. The exosomes act as natural messengers, delivering a complex cargo of growth factors, lipids, salts and nucleic acids in a smartly designed base, to recipient dermal cells, modulating key signalling pathways related to inflammation, collagen synthesis, and cell proliferation.
When applied topically post-procedure, following micro-injury treatments such lasers, chemical peels or microneedling, exosomes migrate into the epidermal layer and release their cargo of biochemicals. Micro-channels created facilitate deep delivery and significantly amplify treatment outcomes, resolving a complex inflammation cascade and stimulating skin rejuvenation. Clinical studies will be presented which show superior results compared to human exosomes, with an 86% greater improvement in fine lines and wrinkles and a 50% increase in firmness after 21 days. This system of mechanical micro injury followed by biochemical signalling via bacterial exosomes and a pro-resolution, lipid-based carrier offers an innovative and effective approach for accelerated skin rejuvenation, scar resolution and barrier repair, with less patient downtime.
Dr Claudia Aguirre
Founder and Principal, doctorclaudia
Biography
Dr. Aguirre is a renowned neuroscientist celebrated for her work illuminating the link between emotional and physical health, notably through her TEDx talk “The Hidden Brain in Your Skin”, which reshaped how we view beauty and well-being. She has advised leading global brands, from wellness apps to spas, pharmaceuticals to herbals, and prestige beauty to indie brands translating complex neuroscience into accessible guidance for global audiences.
Dr. Aguirre’s academic work stems from brain longevity, focusing on the intricate effects of hormonal and environmental factors on early-onset dementia, and the resulting lifestyle changes that can prevent, or even reverse, age-related damage with particular focus on the brain.
Presentation Outline
To be confirmed.
Clare O'Conner
Lead scientist: skin healthy ageing research, Boots No 7 Company
Biography
With over thirty years of experience in the personal care industry Clare has spent two decades researching and developing protection solutions for both beach products and everyday UVR exposure , working internally at Boots No7 Beauty Company and externally with key opinion leaders in UV protection and measurement. She was fundamental in introducing Five Star UVA technology now incorporated across many UK brands since it was introduced in 2004.
From 2010 Clare has been working with external academics, dermatologists, and clinical research institutions on skin healthy ageing research ,understanding and researching the impact of internal and external stressors on skin`s health and appearance. In 2022 she was appointed as honorary lecturer at the University of Manchester supporting education on skin ageing as well as a visiting lecturer at Nottingham Trent University and is currently the chair of the sun products working group at the CTPA.
Presentation: From Selfies to Cells: A Unified Approach to Skin Ageing
By combining well-established methodologies with emerging scientific techniques, artificial intelligence, digital technologies, and consumer science, we create a fully integrated framework for innovation. This approach allows us to harness the rigour of traditional research while leveraging cutting-edge tools to uncover deeper insights into consumer needs and behaviours, product performance, and new biological mechanisms. Through this synergy, we can accelerate discovery, optimise formulations, and deliver solutions that are both scientifically robust and consumer relevant. An example of how this integrated approach has been applied is shared in this presentation.
Professor Fay Bound Alberti
Professor of History specialising in medicine, emotion and the body, and a UKRI Future Leaders Fellow
Biography
Professor Fay Bound Alberti is a Professor of History specialising in medicine, emotion and the body, and a UKRI Future Leaders Fellow. Her research explores how human experience – including emotion, embodiment and wellbeing – is shaped by, and in turn shapes, design, policy, culture and technology.
Alongside her academic work, Fay provides advisory expertise to organisations, technology companies and interdisciplinary research teams, supporting the translation of research into practice across areas including emotion, ethics, innovation and human-centred design. Her work combines rigorous scholarship with a creative sensibility, addressing subjects ranging from the language of the heart and the expressive power of the face to loneliness, connection and emotional life in a digital age.
Since completing her PhD, she has secured over £3.5 million in research funding and has managed philanthropic funding streams exceeding £25 million, demonstrating a strong track record in developing ambitious projects and leading interdisciplinary collaboration across research, policy and practice.
A respected public speaker and writer, Fay regularly contributes to media and public debate, with appearances on BBC Radio 4’s In Our Time, Moral Maze and Thinking Allowed, as well as ABC News and CNN. She has written for The Guardian, TIME, The Lancet and BMJ. Her books include A Biography of Loneliness, This Mortal Coil and Matters of the Heart. Her new book, The Face: A Cultural History, is published by Allen
Presentation: Resting Bitch Face or Calm and Unruffled? Understanding Gender, Ageing and Emotional Expression
Discussions of anti-ageing concerns and ‘youthification’ do not tend enough to the gendering of ageing and expression – in particular, the presumptions made about a person’s inner world as evidenced from their external appearance. Faces are malleable rather than static parts of the body, and how they move, emote and communicate is central to the judgements we make about others and ourselves. It also influences how we feel about ourselves, and the consumer choices we make, from cosmetics to facial surgery.
In this talk, Professor Fay Bound Alberti, author of The Face: A Cultural History explores the cultural and historical meanings of emotional expression. She argues that the facial language of emotions is far more complex than the standard biological model established since Charles Darwin – and that how a person feels, emotes and connects to others must be reframed to include cultural beliefs about ethnicity, gender and age.
Dr Georgios Stamatas
Global Scientific Director, SGS CTS
Biography
Dr Georgios Stamatas has more than 25 years of international experience in the Health Care industry. He is passionate about discovering actionable scientific insights, focusing on the understanding of skin physiology and the effects of topical skin care products. He is leading efforts in pioneering work that ranges from microbiome and metabolome to computational biology and development on non-invasive clinical methods. This research has led to an important number of global “firsts”, including a paradigm shift in our knowledge of infant skin maturation and understanding the mechanisms of cutaneous adverse reactions during oncology therapy. Dr. Stamatas holds a PhD in Chemical/Biomedical Engineering and has co-authored more than 110 peer-review publications and 14 patents.
Presentation: Systems Biology of Aging Skin
Systems biology is an interdisciplinary approach that seeks to understand the complex interactions within biological systems by integrating data across multiple levels of organisation, including genetic, molecular, cellular, and environmental factors. In the context of skin aging, systems biology provides a framework for unraveling the intricate networks and pathways that drive structural and functional changes over time, enabling the identification of pivotal biomarkers and potential therapeutic targets.
Two case studies exemplify different approaches of the application of systems biology principles to skin science. The first employs a cross-omics strategy integrating microbiome profiling and metabolomics. This approach uncovers distinct metabolite–microbe clusters on the skin surface, shedding light on microbial contributions to skin health and aging, and identifying metabolic pathways that may influence skin integrity and resilience. Such integrative analysis enhances understanding of the dynamic interplay between microbes and skin physiology, particularly in the aging process.
The second approach utilises computational agent-based modelling to simulate the three-dimensional structure and self-organising processes of the epidermis. This realistic model captures cellular morphologies, barrier formation, and hydration, facilitating in silico experiments on skin responses and aging-related functional changes. It offers a mechanistic visualisation of skin organisation and emergent properties, providing a valuable tool for studying complex interactions beyond static observations.
Together, these approaches demonstrate the power of systems biology to generate comprehensive insights into skin aging, offering promising avenues for developing targeted, personalised intervention strategies that can effectively delay or reverse age-associated changes.
Dr Holly Wilkinson
Lecturer, University of Hull
Biography
Dr Wilkinson is a Senior Lecturer in Skin Repair and Microbiome research at the Hull York Medical School. She undertook a Knowledge Transfer Partnership at the University of Manchester and Medical Research Council-funded PhD in the field of skin biology. Her interest in skin continued as a research fellow in the Hull York Medical School, where she accepted a faculty position in 2020. In her career, Dr Wilkinson has developed a range of translational skin models to assess the efficacy of novel therapeutics, and she continues to expand her portfolio of academic and industry projects. Fundamentally, her group is interested in understanding how cellular ageing mechanisms are implicated in skin health. She is also utilising cutting-edge transcriptomic and metagenomic approaches to explore host-microbial interactions during skin ageing and wound repair.
Presentation Outline
To be confirmed.
Dr Hugo Corstjens
Consultant, Novigo+
Biography
To be confirmed.
Presentation: Beauty, Science, and Technology: Is Innovation Our Guiding Catalyst?
In an increasingly dynamic and competitive landscape, the cosmetics industry takes pride in prioritising innovation. Innovation is widely regarded as a vital mechanism for developing products that are effective, safe, and environmentally responsible. However, innovation covers a broad range of activities influenced by diverse drivers, motivations, and perspectives. Emerging cross-sector collaborations are poised to play a key role in shaping the industry’s future. But what exactly does the term “innovation” mean, and how can it be implemented? This presentation will offer several insights into this topic, supported by practical examples.
Dr Jule Kexa Volzke
Lead of Product Creation and Development, CLR Berlin GmbH
Biography
Driven by her desire to better understand the big picture, Dr. Jule Lexa Völzke started with the smallest building blocks by studying chemistry at Humboldt University in Berlin. With a research focus on mass spectrometry and method development for protein quantification, she later earned her doctorate in protein analysis at the Federal Institute for Materials Research and Testing. Today, she works as the Lead of Product Creation and Development at CLR Berlin GmbH. With her scientific expertise, she works closely together with CLR’s R&D departments, bridging the gap between consumer needs and science of the skin, with the aim to develop effective skincare solutions.
Presentation: More than the sum of its parts. From complex microorganisms to timeless skin care via fermentation technology
In nature, everything is interconnected. Trying to explain it with an isolated view leads nowhere.
Life began with unicellular organisms that were able to band together to defy all odds. In their community, these species laid the foundation for the evolution of life. Understanding this interaction between bacteria and other microorganisms offers an enormous treasure trove of knowledge.
This presentation highlights the technologies available to us today for harnessing the benefits of these micro-organism-based systems in the development of active ingredients for skin care, their biological effects, and what this ultimately means for consumers in real life.
Be it a rich mix derived from microorganisms, the skin as a miraculous organ, or ourselves as a whole.
Everything is more than the sum of its parts.
Dr Katja Bartsch
Postdoctoral researcher, Technical University Munich, School of Medicine and Health
Biography
Dr Katja Bartsch is a postdoctoral researcher at the Technical University of Munich, School of Medicine and Health. Her research focuses on the biomechanics of connective tissues, with a particular interest in fascia as a hormonally and mechanically responsive structure relevant to ageing, performance, and well-being. She earned her doctorate and MBA from Friedrich-Alexander-Universität Erlangen-Nürnberg and has been a visiting research fellow at the University of Jyväskylä in Finland.
Dr Bartsch has authored numerous research articles and book chapters, including her book Optimizing Women’s Health through Exercise: A Scientific Approach to Training and Performance. She was awarded second prize for scientific presentations at the International Fascia Research Congress in Montréal. Trained in fascia-oriented manual techniques, she also serves as a Research Advisor for the European Rolfing Association e.V.. Drawing on over a decade of experience as a movement and yoga educator, Dr Bartsch bridges biomechanical research and practical application.
Her current work positions the facial fascia as an emerging target tissue in anti-ageing research, linking biomechanical and neurophysiological activation with systemic aspects of longevity and well-being.
Presentation: Beyond the Skin: Fascia as Emerging Target Tissue in Longevity and Well-Being
Fascia is increasingly recognised as a dynamic organ-system influencing ageing, musculoskeletal function and overall well-being. This presentation outlines the structural and functional diversity of fascial tissues—including superficial, deep, visceral and neural layers—with emphasis on the SMAS as a key facial component. We highlight fascia’s biomechanical properties, current measurement methods such as shear-wave elastography, and factors that shape stiffness and elasticity across the lifespan.
Emerging evidence links fascia to endocrine and immune activity, including interactions with female sex hormones, lymphatic flow and inflammatory pathways. Its rich sensory and autonomic innervation also positions fascia as a mediator of emotional and physical well-being, particularly in response to touch and massage.
Integrating mechanobiology and systems-level insights, fascia can be understood as a central node within the neuro-immuno-mechanical network of ageing. This perspective positions fascial tissues as promising targets for practitioner-applied and self-administered interventions, with potential relevance for anti-ageing, longevity and overall well-being.
Dr Klodjan Stafa
Founder, CutaneoX BioStrategies LLC
Biography
Dr Klodjan Stafa is a biomedical research leader with over 15 years of experience at the intersection of skin biology, neuroscience and ageing, with deep expertise in inflammation, epigenetics, bioenergetics and cell-to-cell communication relevant to skin longevity. Formerly Associate Director of R&D at The Estée Lauder Companies and now Founder of CutaneoX BioStrategies, he drives science-led anti-ageing innovation by translating advanced molecular and cellular insights into clinically and commercially impactful skincare solutions.
Presentation: Hormetic Stress, Longevity Pathways, and Cutaneous Ageing: Molecular Circuits Linking Muscle, Adipose, and Neuroendocrine Signals to Skin Health span
Skin aging results from local cell decline combined with body-wide metabolic, immune, and neuroendocrine changes. Recent studies show that the skin acts as an active barrier that senses and reacts to signs of aging in the entire body. This talk explores how hormetic stressors, especially resistance exercise and cold exposure, activate pathways linked to longevity, which produce hormones that can alter skin aging. Mechanical and metabolic stress during resistance training triggers AMPK-PGC-1α signaling, increases NAD⁺ levels and boosts SIRT1/3 activity, leading to better mitochondrial growth, the removal of damaged mitochondria, and less oxidative harm in dermal fibroblasts. The activation of FOXO transcription factors enhances antioxidant defenses and reduces inflammation linked to aging. At the same time, muscle-derived myokines such as irisin and IL-15 improve how mitochondria work, help maintain the extracellular matrix, and facilitate immune surveillance of senescent cells. Cold exposure activates β-adrenergic signaling and changes the way brown and beige fat cells produce heat. This process reduces mTOR-AKT signaling, increases autophagic flow, and activates the NRF2 pathway, increasing cellular resilience in keratinocytes and fibroblasts. Batokines like FGF21 and Nrg4 also play a role in managing inflammation, metabolic balance, and the stability of small blood vessels, all of which influence dermal integrity.
Together, these hormonal and molecular signals come together to address key issues in skin aging, such as mitochondrial, including mitochondrial dysfunction, inflammageing, breakdown of the extracellular matrix and weakened barrier function. By outlining these mechanistic connections, this lecture redefines the skin as a responsive part of the body’s stress response and suggests that carefully timed exercise and cold exposure could enhance dermatological treatments aimed at prolonging cutaneous health span.
Luc Aguilar
Chief Scientific Officer for Advanced Research, L’Oréal
Biography
Dr Luc AGUILAR has over 25 years of extensive experience spanning the biotech, pharmaceutical, and cosmetics industries. He joined the L’Oréal Group 15 years ago to successfully pivote the company’s research efforts from oil-based to green and biotechnology-derived ingredients.
Following this, he led R&D teams dedicated to the cutting-edge fields of Skin Microbiome and Exposome. His leadership delivered innovative products in photoprotection, pigmentation, aging, and compromised skin conditions including acne and eczema.
Prior to his tenure at L’Oréal, from 2005 to 2011, Luc served at the Pierre Fabre Group, a mid-sized pharmaceutical company, where he advised the President on scientific and biotechnology affairs.
An engineer by training, he earned his Ph.D. in Molecular Biology from Sorbonne University in Paris.
Currently, Luc AGUILAR holds the position of Chief Scientific Officer for L’Oréal Advanced Research, continuing to drive scientific innovation within the company.
Presentation: Unlocking ageless beauty with the skin microbiome revolution
The pursuit of beauty is evolving beyond the constraints of chronological age, entering a new era focused on longevity – encompassing healthspan, beautyspan, and mentalspan. The skin microbiome, the complex community of microorganisms residing on the skin’s surface plays a crucial role in maintaining skin health and influencing the aging process. L’Oréal’s research has explored the intricate relationship between the composition and diversity of the skin microbiome and various aging parameters in the new frame of Longevity. Studies have shown that age-related changes in the microbiome can impact skin hydration, barrier function, and even the development of specific aging signs like wrinkles and dark spots. This research underscores the potential of leveraging the skin microbiome to promote healthy aging through diagnostics to pave the way for innovative skincare solutions.
Dr Max Brown
Senior Scientist, Proctor & Gamble
Biography
Dr Max Brown is a project leader in an upstream research team focused on gaining mechanistic insights into the ageing of skin and the underlying molecular biology. Max received his PhD in Molecular and Cellular Biology from Durham University (UK). His postdoctoral studies were completed in Durham and Northumbria University where he created new tools to monitor live cell collagen trafficking and studied the role of proteostasis in skin fibrosis and inflammation. Max started his industry career as an R&D project manager for FibroFind screening new anti-fibrotic compounds to de-risk clinical trials. Since joining P&G 3 years ago he has led anti-ageing skin care projects and represents P&G to advocate for consumer skin health via his work in BSI and Cosmetics Europe Sun Protection. Max is responsible for identifying fundamental insights into skin ageing to identify new technologies that deliver consumer benefits.
Presentation: Hallmarks of Skin Aging: Systems-Level Mapping of Molecular Pathways Driving Skin Longevity
Skin is a vital organ that protects the body, supports sensory function, and contributes to wellbeing and social confidence. As life expectancy increases, maintaining healthy skin throughout life has become an important aspect of healthy ageing. Understanding how the skin ages at a biological level is key to identifying new ways to improve skin function and appearance for consumer benefit.
Building on the Hallmarks of Aging (HoA), we used a systems-biology approach to explore how ageing and photoexposure affect skin at the molecular level. We analysed photoexposed (face, arm) and photoprotected (buttock) sites from women aged 20s to 70s using histology, transcriptomics, proteomics, and skin surface biomarker data. This integrative, multi-omics design enabled us to map interconnected pathways and cellular processes impacted by chronological and environmental ageing.
Our analysis revealed coordinated alterations across nearly all HoA pathways, including senescence onset, chronic low-grade inflammation (inflammaging), mitochondrial dysfunction, epigenetic drift, and impaired intercellular communication. Disruption of epidermal homeostasis appeared early in adulthood, likely driven by sustained inflammatory signalling. These data support the concept of cutaneous inflammaging, reflecting the skin’s constant environmental exposure, particularly to solar radiation.
Recent systems-level approaches will be presented demonstrating how they have been applied to better understand both dermal and epidermal skin biology. We investigated collagen proteostasis in the dermis to identify new skin care ingredient combinations. Whilst spatial transcriptomics and single-cell analyses, have revealed the impact of Galactomyces ferment filtrate and where these molecular interactions occur within the skin microenvironment.
By mapping these processes through a systems biology lens, we can begin to see how the Hallmarks of Skin Ageing reveal key biological targets that could be addressed to help maintain or restore skin longevity. These insights support the development of interventions that aim to improve skin health, resilience, and appearance for long-term consumer skin care benefits.
Mike Hoptroff
R&D Manager, Unilever
Biography
Michael joined Unilever in 1998 and has over 27 years’ experience in R&D with a particular focus on skin biology, scalp biology and the microbiome.
In 2005 Mike led the R&D programme for Lifebuoy bar and liquid reformulation including tracking how handwashing behaviour intervention reduces disease incidence in one of Unilever’s largest ever public health intervention study’s. 2008 saw a move to the Hair business with a pivot to scalp biology, antidandruff and the start of eight years working on scalp biology and dandruff. During this time Mike also led the establishment of the Shanghai bioscience team during a four year relocation to China.
Since returning to the Uk in 2016 Mike has helped to lead microbiome research for Beauty and Personal Care, delivering technology for Dove, Signal, PONDS and others, he has also contributed to the UK strategy on microbiome research, the Microbiome Innovation Centre at the University of Liverpool; the latest stage in a near 20year partnership between the University and Unilever in microbiome research. During his career Mike has authored over 28 publications on microbiome, skin biology and dandruff.
Presentation: The microbiome of skin ageing
The skin microbiome colonises follicles and forms the outermost layer of skin, providing protective and nutritional benefits to the skin beneath. As we age, so our skin microbiome changes, the microbiome of infants is distinct from that of adolescents, which in turn is distinct from that of young adults, middle and older age. The trajectory of this change is reproducible across studies, with several publications reporting the successful use of skin microbiome data to predict chronological age. In addition to chronological aging, recent work has highlighted that physiological changes in premature aging and daily stress may also impact associated changes in the microbiome impacting both the taxonomic composition of the microbiome and the functional changes through which it might affect skin condition.
Dr Nükhet Cavusoglu
Head of High-Throughput Biology and Diagnostic platform, L’Oréal
Biography
To be confirmed.
Presentation Outline
To be confirmed.
Olivia Santoni
CEO, Bloom Regulatory Ltd
Biography
Olivia Santoni has an extensive knowledge of the cosmetics industry globally and over 20 ears of practical experience. She studied business law and healthcare product law before specialising in regulatory affairs.
She started her regulatory career working as a medical device regulatory inspector at the French Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). She then worked at the international department of the French cosmetics trade association (FEBEA) before moving to the UK and joining the UK Cosmetics Toiletry and Perfumery Association (CTPA).
Over the years, Olivia managed a regulatory and international team to deliver support and advice to companies as well as advocate for the interest of the UK and EU industry. She has led the UK Association’s work on Brexit and international regulatory affairs and has been an active participant at Cosmetics Europe groups on both regulatory and international issues.
In 2019, Olivia decided to found Bloom Regulatory Ltd to provide pragmatic and expert regulatory and strategic support to cosmetics companies in a world where business opportunities are growing but legislations are increasing and getting more and more complex.
Presentation: Understanding the regulatory landscape: Translating science in cosmetic product development into marketing claims
The science of skin ageing and systems biology is evolving and creating new opportunities for scientists and industry. Launching new skincare products inspired by the latest scientific knowledge in this area will have to carefully navigate the regulatory requirements surrounding classification, claims compliance and substantiation. This presentation will provide an introduction to the regulatory framework and key considerations regarding claims on systems biology and skin ageing.
A future deeper understanding of systems biology, combined with thoughtful interpretation of regulatory guidelines in the US and UK/Europe, will not only ensure credible and compliant product claims but also shape the industry’s ability to lead innovation, build consumer trust, and set the standard for next-generation skincare enhancing skin health and wellbeing.
Professor Paul Matts
Retired R&D Vice President, Procter & Gamble
Biography
Paul joined Procter & Gamble (P&G) in 1988 as a PhD Microbial biochemist and spent the majority of his career leading various aspects of Skin Research, working across most of the Company’s Operating Units (as he maintains that all of them touch the human skin in some way!). He retired from P&G in 2024.
He is a Visiting Professor to the London College of Fashion and past Visiting Professor to the UCL School of Pharmacy. He is a past Chair of the Cosmetics Europe (CE) Sun Protection Methods Task Force, the standardIsation of SPF and UVA methods.
In his spare time, he re-applies his skin biology expertise to resource-poor settings and, in 2012, co-founded an NGO in Ethiopia to help the 1.5+ million sufferers of Podoconiosis (non-filarial, lower-leg lymphoedema).
He is married to Ali, has 3 grown-up children and is recently a grandfather! He loves the outdoors… running, mountains, scuba-diving and, in 2013, bought an old, run-down property on the Isle of Mull which he thinks is a small piece of Heaven.
Presentation Outline
To be confirmed.
Professor Rachel Watson
Executive Director, A*STAR Skin Research Lab (A* SRL)
Biography
Rachel Watson was Professor of Cutaneous Science at the University of Manchester (UK), prior to her appointment as Executive Director of both the A*STAR Skin Research Labs and the Skin Research Institute of Singapore in 2023. She received her BSc (Anatomy & Cell Biology) and PhD degrees from the University of Sheffield, UK.
Passionate about geroscience, Rachel’s research includes understanding the mechanisms which lead to skin ageing (both intrinsic and that augmented by the environment) and the assessment of extracellular matrix repair, particularly by topical retinoids.
Presentation: The skin: A window of opportunity for healthy ageing?
After decades of cutaneous research – often focused on the ‘favourite’ pathways of the individual researcher – we now appreciate the exquisite complexity of skin and how its biology changes as we age. Our environment – and our conduct in it – impacts skin health greatly, the exposome influencing multiple pathways to alter skin behaviour, appearance and disease prevalence. Arguably the body’s largest organ, the opportunity for the skin to affect systemic health is now becoming apparent; physiological processes associated with skin ageing influence, and are influenced by, systemic ageing processes. This provides us, as researchers, with unprecedented opportunities to modulate skin health to influence – and potentially improve – systemic health, and vice versa. We cannot study skin in isolation; instead, we must adopt a holistic approach to our research, to better serve patients and consumers in the quest for both skin and systemic health.
Dr Katerina Steventon
Anti-Ageing Skin Care Conference Director
SPEAKER TOPIC
To be confirmed
Biography
Dr Katerina Steventon is a skincare specialist with over 25 years’ global experience across clinical, commercial and research settings, holding an MSc in Clinical Biochemistry and a PhD in Transdermal Absorptions. She has deep expertise in skin biology, ageing and translational innovation, and runs an innovation consultancy focused on functional skincare informed by cross-cultural consumer insights.
Presentation Outline
To be confirmed.
Andrew McDougall
Director of Insights, Beauty & Personal Care
SPEAKER TOPIC
Consumer and technology trends shaping the next era of longevity skincare
Biography
Andrew is an innovative, competent and successful analyst and journalist, with a particular focus on the beauty sector. Since joining Mintel in 2016, he has led the team on trends, delivered projects to clients around the world, featured at the biggest and best beauty industry events, and brings over a decade of experience in the market. He has also been integral in the development of many AV initiatives, such as webinars and podcasts.
Presentation Outline
As the anti-ageing category evolves, a new paradigm is emerging; one rooted in systems biology and a deep understanding of the biological processes that underpin skin ageing. This session will explore how cutting-edge science, from the 12 Hallmarks of Ageing to cellular repair and the skin microbiome, is reshaping both product innovation and consumer expectations. We’ll examine why consumers are increasingly seeking preventative, holistic, and personalised solutions; and how technology, from advanced actives to diagnostics and delivery systems, is making these aspirations a reality. Gain actionable strategies for translating complex longevity science into relatable, credible benefits that resonate with today’s health-centric, empowered consumer, ensuring brands stand out in the next era of anti-ageing skincare.
Biography
Dr Anjali Mahto is a London-based Consultant Dermatologist and founder of Self London, with specialist expertise in acne, acne scarring, cutaneous ageing and evidence-based non-surgical rejuvenation. She is the author of the international bestseller ‘The Skincare Bible’ and a leading independent clinical voice, focused on improving standards, transparency, and patient-centred, outcomes-driven care in aesthetic dermatology.
Presentation Outline
To be confirmed.
Dr Ardeshir Bayat
Physician-Scientist (MD, PhD)
SPEAKER TOPIC
To be confirmed
Biography
A results-driven Physician–Scientist (MD, PhD) – Dr Ardeshir Bayat brings over 20 years of experience leading global innovation across the healthcare and skincare sectors. His work is driven by a commitment to advancing human health through science-led, consumer- and patient-centric product development, with deep expertise in skin health, cutaneous inflammation and dermal fibrosis.
He has led programmes across the full R&D lifecycle, from in silico, in vitro and ex vivo research through to global clinical trials and post-market development, consistently applying rigorous scientific and clinical standards. He has a strong track record of shaping global R&D and medical affairs strategies and guiding products from concept to successful commercialisation across pharmaceutical and cosmetic industries.
A strategic and collaborative leader, he has driven growth and sustained innovation within both start-ups and multinational organisations, building high-performing, multidisciplinary teams across the US, UK, Europe, Asia and Africa. His core competencies include global clinical development, R&D oversight, product and brand strategy, regulatory and medical affairs, intellectual property strategy and market insight.
Internationally recognised in skin health, cutaneous healing and dermal fibrosis, he has authored over 520 publications, holds more than 50 patents and has delivered more than 660 keynote presentations worldwide
Presentation Outline
To be confirmed.
Dr Bob Bianchini
Chief Scientist
SPEAKER TOPIC
Bacterial Exosome System Combined with Micro-Injury Treatments for Enhanced Skin Rejuvenation: A Systems Biology Approach
Biography
Dr Robert Bianchini Vice-President Research and Innovation at Dermalogica, A Unilever Prestige Co. is a senior research scientist at Dermalogica, bringing extensive expertise in skin biology, cosmetic science and product innovation. With a strong background in applied research, Bob plays a key role in advancing Dermalogica’s evidence-based approach to skincare, supporting the development of high-performance formulations grounded in robust scientific understanding.
His work focuses on skin physiology, barrier function and the interaction between formulations and the skin, helping translate complex biological processes into practical, effective skincare solutions. Bob collaborates closely with cross-functional teams across research, formulation, testing and marketing to ensure scientific insights are embedded throughout the product development lifecycle.
At Dermalogica, he contributes to research strategy, data interpretation and technical validation, supporting claims substantiation and innovation aligned with both consumer needs and regulatory expectations. He is particularly experienced in bridging laboratory research with real-world application, ensuring that science-led innovation delivers tangible benefits for skin health.
Dr Bianchini is also an engaging industry speaker, valued for his ability to communicate complex skin science clearly and credibly to professional and commercial audiences.
Presentation Outline
Aging skin is characterised by a decline in cellular communication, skin imperfections and regenerative capacity, manifesting as fine lines, wrinkles, sagging, color variation and reduced firmness. Dermalogica PRO Exo Booster system is a novel, non-human derived exosome system which employs a systems biology-based approach to skin health. Utilising 10 billion Lactobacillus exosomes per treatment in an Omega 3-based delivery vehicle, it significantly enhances intercellular communication and rejuvenation. The exosomes act as natural messengers, delivering a complex cargo of growth factors, lipids, salts and nucleic acids in a smartly designed base, to recipient dermal cells, modulating key signalling pathways related to inflammation, collagen synthesis, and cell proliferation.
When applied topically post-procedure, following micro-injury treatments such lasers, chemical peels or microneedling, exosomes migrate into the epidermal layer and release their cargo of biochemicals. Micro-channels created facilitate deep delivery and significantly amplify treatment outcomes, resolving a complex inflammation cascade and stimulating skin rejuvenation. Clinical studies will be presented which show superior results compared to human exosomes, with an 86% greater improvement in fine lines and wrinkles and a 50% increase in firmness after 21 days. This system of mechanical micro injury followed by biochemical signalling via bacterial exosomes and a pro-resolution, lipid-based carrier offers an innovative and effective approach for accelerated skin rejuvenation, scar resolution and barrier repair, with less patient downtime.
Biography
Dr. Aguirre is a renowned neuroscientist celebrated for her work illuminating the link between emotional and physical health, notably through her TEDx talk “The Hidden Brain in Your Skin”, which reshaped how we view beauty and well-being. She has advised leading global brands, from wellness apps to spas, pharmaceuticals to herbals, and prestige beauty to indie brands translating complex neuroscience into accessible guidance for global audiences.
Dr. Aguirre’s academic work stems from brain longevity, focusing on the intricate effects of hormonal and environmental factors on early-onset dementia, and the resulting lifestyle changes that can prevent, or even reverse, age-related damage with particular focus on the brain.
Presentation Outline
To be confirmed.
Clare O'Conner
Lead scientist: skin healthy ageing research
SPEAKER TOPIC
From Selfies to Cells: A Unified Approach to Skin Ageing
Biography
With over thirty years of experience in the personal care industry Clare has spent two decades researching and developing protection solutions for both beach products and everyday UVR exposure , working internally at Boots No7 Beauty Company and externally with key opinion leaders in UV protection and measurement. She was fundamental in introducing Five Star UVA technology now incorporated across many UK brands since it was introduced in 2004.
From 2010 Clare has been working with external academics, dermatologists, and clinical research institutions on skin healthy ageing research ,understanding and researching the impact of internal and external stressors on skin`s health and appearance. In 2022 she was appointed as honorary lecturer at the University of Manchester supporting education on skin ageing as well as a visiting lecturer at Nottingham Trent University and is currently the chair of the sun products working group at the CTPA.
Presentation Outline
By combining well-established methodologies with emerging scientific techniques, artificial intelligence, digital technologies, and consumer science, we create a fully integrated framework for innovation. This approach allows us to harness the rigour of traditional research while leveraging cutting-edge tools to uncover deeper insights into consumer needs and behaviours, product performance, and new biological mechanisms. Through this synergy, we can accelerate discovery, optimise formulations, and deliver solutions that are both scientifically robust and consumer relevant. An example of how this integrated approach has been applied is shared in this presentation.
Professor Fay Bound-Alberti
Professor of History
SPEAKER TOPIC
Resting Bitch Face or Calm and Unruffled? Understanding Gender, Ageing and Emotional Expression
Biography
Professor Fay Bound Alberti is a Professor of History specialising in medicine, emotion and the body, and a UKRI Future Leaders Fellow. Her research explores how human experience – including emotion, embodiment and wellbeing – is shaped by, and in turn shapes, design, policy, culture and technology.
Alongside her academic work, Fay provides advisory expertise to organisations, technology companies and interdisciplinary research teams, supporting the translation of research into practice across areas including emotion, ethics, innovation and human-centred design. Her work combines rigorous scholarship with a creative sensibility, addressing subjects ranging from the language of the heart and the expressive power of the face to loneliness, connection and emotional life in a digital age.
Since completing her PhD, she has secured over £3.5 million in research funding and has managed philanthropic funding streams exceeding £25 million, demonstrating a strong track record in developing ambitious projects and leading interdisciplinary collaboration across research, policy and practice.
A respected public speaker and writer, Fay regularly contributes to media and public debate, with appearances on BBC Radio 4’s In Our Time, Moral Maze and Thinking Allowed, as well as ABC News and CNN. She has written for The Guardian, TIME, The Lancet and BMJ. Her books include A Biography of Loneliness, This Mortal Coil and Matters of the Heart. Her new book, The Face: A Cultural History, is published by Allen
Presentation Outline
Discussions of anti-ageing concerns and ‘youthification’ do not tend enough to the gendering of ageing and expression – in particular, the presumptions made about a person’s inner world as evidenced from their external appearance. Faces are malleable rather than static parts of the body, and how they move, emote and communicate is central to the judgements we make about others and ourselves. It also influences how we feel about ourselves, and the consumer choices we make, from cosmetics to facial surgery.
In this talk, Professor Fay Bound Alberti, author of The Face: A Cultural History explores the cultural and historical meanings of emotional expression. She argues that the facial language of emotions is far more complex than the standard biological model established since Charles Darwin – and that how a person feels, emotes and connects to others must be reframed to include cultural beliefs about ethnicity, gender and age.
Biography
Dr Georgios Stamatas has more than 25 years of international experience in the Health Care industry. He is passionate about discovering actionable scientific insights, focusing on the understanding of skin physiology and the effects of topical skin care products. He is leading efforts in pioneering work that ranges from microbiome and metabolome to computational biology and development on non-invasive clinical methods. This research has led to an important number of global “firsts”, including a paradigm shift in our knowledge of infant skin maturation and understanding the mechanisms of cutaneous adverse reactions during oncology therapy. Dr. Stamatas holds a PhD in Chemical/Biomedical Engineering and has co-authored more than 110 peer-review publications and 14 patents.
Presentation Outline
Systems biology is an interdisciplinary approach that seeks to understand the complex interactions within biological systems by integrating data across multiple levels of organisation, including genetic, molecular, cellular, and environmental factors. In the context of skin aging, systems biology provides a framework for unraveling the intricate networks and pathways that drive structural and functional changes over time, enabling the identification of pivotal biomarkers and potential therapeutic targets.
Two case studies exemplify different approaches of the application of systems biology principles to skin science. The first employs a cross-omics strategy integrating microbiome profiling and metabolomics. This approach uncovers distinct metabolite–microbe clusters on the skin surface, shedding light on microbial contributions to skin health and aging, and identifying metabolic pathways that may influence skin integrity and resilience. Such integrative analysis enhances understanding of the dynamic interplay between microbes and skin physiology, particularly in the aging process.
The second approach utilises computational agent-based modelling to simulate the three-dimensional structure and self-organising processes of the epidermis. This realistic model captures cellular morphologies, barrier formation, and hydration, facilitating in silico experiments on skin responses and aging-related functional changes. It offers a mechanistic visualisation of skin organisation and emergent properties, providing a valuable tool for studying complex interactions beyond static observations.
Together, these approaches demonstrate the power of systems biology to generate comprehensive insights into skin aging, offering promising avenues for developing targeted, personalised intervention strategies that can effectively delay or reverse age-associated changes.
Dr Holly Wilkinson
Senior Lecturer
SPEAKER TOPIC
Ageing Under the Molecular Microscope: Using Spatial Transcriptomics to Uncover Mechanisms of Skin Ageing and Repair
Biography
Dr Wilkinson is a Senior Lecturer in Skin Repair and Microbiome research at the Hull York Medical School. She undertook a Knowledge Transfer Partnership at the University of Manchester and Medical Research Council-funded PhD in the field of skin biology. Her interest in skin continued as a research fellow in the Hull York Medical School, where she accepted a faculty position in 2020. In her career, Dr Wilkinson has developed a range of translational skin models to assess the efficacy of novel therapeutics, and she continues to expand her portfolio of academic and industry projects. Fundamentally, her group is interested in understanding how cellular ageing mechanisms are implicated in skin health. She is also utilising cutting-edge transcriptomic and metagenomic approaches to explore host-microbial interactions during skin ageing and wound repair.
Presentation Outline
To be confirmed.
Dr Hugo Corstjens
Consultant
SPEAKER TOPIC
Beauty, Science, and Technology: Is Innovation Our Guiding Catalyst?
Biography
Hugo Corstjens holds a Master of Science degree from KULeuven (Belgium) and a PhD from the Department of Biomedical Engineering at TUDelft (the Netherlands). He has extensive experience in cosmetics R&D. He spent over 20 years at ELC, where he served as Executive Manager of Basic Science Research and Advanced Technologies. In 2018, he founded Novigo+ to provide independent consulting services for cosmetic companies. His focus is on next-generation technologies to advance cosmetic skin research and support product development and conceptualisation. Hugo has published more than 30 peer-reviewed scientific papers, book chapters, and patent applications. He is a member of several leading expert networks.
Presentation Outline
In an increasingly dynamic and competitive landscape, the cosmetics industry takes pride in prioritising innovation. Innovation is widely regarded as a vital mechanism for developing products that are effective, safe, and environmentally responsible. However, innovation covers a broad range of activities influenced by diverse drivers, motivations, and perspectives. Emerging cross-sector collaborations are poised to play a key role in shaping the industry’s future. But what exactly does the term “innovation” mean, and how can it be implemented? This presentation will offer several insights into this topic, supported by practical examples.
Dr Jule Lexa Volzke
Lead of Product Creation and Development
SPEAKER TOPIC
More than the sum of its parts. From complex microorganisms to timeless skin care via fermentation technology
Biography
Driven by her desire to better understand the big picture, Dr. Jule Lexa Völzke started with the smallest building blocks by studying chemistry at Humboldt University in Berlin. With a research focus on mass spectrometry and method development for protein quantification, she later earned her doctorate in protein analysis at the Federal Institute for Materials Research and Testing. Today, she works as the Lead of Product Creation and Development at CLR Berlin GmbH. With her scientific expertise, she works closely together with CLR’s R&D departments, bridging the gap between consumer needs and science of the skin, with the aim to develop effective skincare solutions.
Presentation Outline
In nature, everything is interconnected. Trying to explain it with an isolated view leads nowhere.
Life began with unicellular organisms that were able to band together to defy all odds. In their community, these species laid the foundation for the evolution of life. Understanding this interaction between bacteria and other microorganisms offers an enormous treasure trove of knowledge.
This presentation highlights the technologies available to us today for harnessing the benefits of these micro-organism-based systems in the development of active ingredients for skin care, their biological effects, and what this ultimately means for consumers in real life.
Be it a rich mix derived from microorganisms, the skin as a miraculous organ, or ourselves as a whole.
Everything is more than the sum of its parts.
Dr Katja Bartsch
Postdoctoral Researcher
SPEAKER TOPIC
Beyond the Skin: Fascia as Emerging Target Tissue in Longevity and Well-Being
Biography
Dr Katja Bartsch is a postdoctoral researcher at the Technical University of Munich, School of Medicine and Health. Her research focuses on the biomechanics of connective tissues, with a particular interest in fascia as a hormonally and mechanically responsive structure relevant to ageing, performance, and well-being. She earned her doctorate and MBA from Friedrich-Alexander-Universität Erlangen-Nürnberg and has been a visiting research fellow at the University of Jyväskylä in Finland.
Dr Bartsch has authored numerous research articles and book chapters, including her book Optimizing Women’s Health through Exercise: A Scientific Approach to Training and Performance. She was awarded second prize for scientific presentations at the International Fascia Research Congress in Montréal. Trained in fascia-oriented manual techniques, she also serves as a Research Advisor for the European Rolfing Association e.V.. Drawing on over a decade of experience as a movement and yoga educator, Dr Bartsch bridges biomechanical research and practical application.
Her current work positions the facial fascia as an emerging target tissue in anti-ageing research, linking biomechanical and neurophysiological activation with systemic aspects of longevity and well-being.
Presentation Outline
Fascia is increasingly recognised as a dynamic organ-system influencing ageing, musculoskeletal function and overall well-being. This presentation outlines the structural and functional diversity of fascial tissues—including superficial, deep, visceral and neural layers—with emphasis on the SMAS as a key facial component. We highlight fascia’s biomechanical properties, current measurement methods such as shear-wave elastography, and factors that shape stiffness and elasticity across the lifespan.
Emerging evidence links fascia to endocrine and immune activity, including interactions with female sex hormones, lymphatic flow and inflammatory pathways. Its rich sensory and autonomic innervation also positions fascia as a mediator of emotional and physical well-being, particularly in response to touch and massage.
Integrating mechanobiology and systems-level insights, fascia can be understood as a central node within the neuro-immuno-mechanical network of ageing. This perspective positions fascial tissues as promising targets for practitioner-applied and self-administered interventions, with potential relevance for anti-ageing, longevity and overall well-being.
Dr Klodjan Stafa
Founder
SPEAKER TOPIC
Hormetic Stress, Longevity Pathways, and Cutaneous Ageing: Molecular Circuits Linking Muscle, Adipose, and Neuroendocrine Signals to Skin Health span
Biography
Dr Klodjan Stafa is a biomedical research leader with over 15 years of experience at the intersection of skin biology, neuroscience and ageing, with deep expertise in inflammation, epigenetics, bioenergetics and cell-to-cell communication relevant to skin longevity. Formerly Associate Director of R&D at The Estée Lauder Companies and now Founder of CutaneoX BioStrategies, he drives science-led anti-ageing innovation by translating advanced molecular and cellular insights into clinically and commercially impactful skincare solutions.
Presentation Outline
Skin aging results from local cell decline combined with body-wide metabolic, immune, and neuroendocrine changes. Recent studies show that the skin acts as an active barrier that senses and reacts to signs of aging in the entire body. This talk explores how hormetic stressors, especially resistance exercise and cold exposure, activate pathways linked to longevity, which produce hormones that can alter skin aging. Mechanical and metabolic stress during resistance training triggers AMPK-PGC-1α signaling, increases NAD⁺ levels and boosts SIRT1/3 activity, leading to better mitochondrial growth, the removal of damaged mitochondria, and less oxidative harm in dermal fibroblasts. The activation of FOXO transcription factors enhances antioxidant defenses and reduces inflammation linked to aging. At the same time, muscle-derived myokines such as irisin and IL-15 improve how mitochondria work, help maintain the extracellular matrix, and facilitate immune surveillance of senescent cells. Cold exposure activates β-adrenergic signaling and changes the way brown and beige fat cells produce heat. This process reduces mTOR-AKT signaling, increases autophagic flow, and activates the NRF2 pathway, increasing cellular resilience in keratinocytes and fibroblasts. Batokines like FGF21 and Nrg4 also play a role in managing inflammation, metabolic balance, and the stability of small blood vessels, all of which influence dermal integrity.
Together, these hormonal and molecular signals come together to address key issues in skin aging, such as mitochondrial, including mitochondrial dysfunction, inflammageing, breakdown of the extracellular matrix and weakened barrier function. By outlining these mechanistic connections, this lecture redefines the skin as a responsive part of the body’s stress response and suggests that carefully timed exercise and cold exposure could enhance dermatological treatments aimed at prolonging cutaneous health span.
Dr Luc Aguilar
Chief Scientific Officer for Advanced Research
SPEAKER TOPIC
Unlocking ageless beauty with the skin microbiome revolution
Biography
Dr Luc AGUILAR has over 25 years of extensive experience spanning the biotech, pharmaceutical, and cosmetics industries. He joined the L’Oréal Group 15 years ago to successfully pivote the company’s research efforts from oil-based to green and biotechnology-derived ingredients.
Following this, he led R&D teams dedicated to the cutting-edge fields of Skin Microbiome and Exposome. His leadership delivered innovative products in photoprotection, pigmentation, aging, and compromised skin conditions including acne and eczema.
Prior to his tenure at L’Oréal, from 2005 to 2011, Luc served at the Pierre Fabre Group, a mid-sized pharmaceutical company, where he advised the President on scientific and biotechnology affairs.
An engineer by training, he earned his Ph.D. in Molecular Biology from Sorbonne University in Paris.
Currently, Luc AGUILAR holds the position of Chief Scientific Officer for L’Oréal Advanced Research, continuing to drive scientific innovation within the company.
Presentation Outline
The pursuit of beauty is evolving beyond the constraints of chronological age, entering a new era focused on longevity – encompassing healthspan, beautyspan, and mentalspan. The skin microbiome, the complex community of microorganisms residing on the skin’s surface plays a crucial role in maintaining skin health and influencing the aging process. L’Oréal’s research has explored the intricate relationship between the composition and diversity of the skin microbiome and various aging parameters in the new frame of Longevity. Studies have shown that age-related changes in the microbiome can impact skin hydration, barrier function, and even the development of specific aging signs like wrinkles and dark spots. This research underscores the potential of leveraging the skin microbiome to promote healthy aging through diagnostics to pave the way for innovative skincare solutions.
Dr Max Brown
Senior Scientist
SPEAKER TOPIC
Hallmarks of Skin Aging: Systems-Level Mapping of Molecular Pathways Driving Skin Longevity
Biography
Dr Max Brown is a project leader in an upstream research team focused on gaining mechanistic insights into the ageing of skin and the underlying molecular biology. Max received his PhD in Molecular and Cellular Biology from Durham University (UK). His postdoctoral studies were completed in Durham and Northumbria University where he created new tools to monitor live cell collagen trafficking and studied the role of proteostasis in skin fibrosis and inflammation. Max started his industry career as an R&D project manager for FibroFind screening new anti-fibrotic compounds to de-risk clinical trials. Since joining P&G 3 years ago he has led anti-ageing skin care projects and represents P&G to advocate for consumer skin health via his work in BSI and Cosmetics Europe Sun Protection. Max is responsible for identifying fundamental insights into skin ageing to identify new technologies that deliver consumer benefits.
Presentation Outline
Skin is a vital organ that protects the body, supports sensory function, and contributes to wellbeing and social confidence. As life expectancy increases, maintaining healthy skin throughout life has become an important aspect of healthy ageing. Understanding how the skin ages at a biological level is key to identifying new ways to improve skin function and appearance for consumer benefit.
Building on the Hallmarks of Aging (HoA), we used a systems-biology approach to explore how ageing and photoexposure affect skin at the molecular level. We analysed photoexposed (face, arm) and photoprotected (buttock) sites from women aged 20s to 70s using histology, transcriptomics, proteomics, and skin surface biomarker data. This integrative, multi-omics design enabled us to map interconnected pathways and cellular processes impacted by chronological and environmental ageing.
Our analysis revealed coordinated alterations across nearly all HoA pathways, including senescence onset, chronic low-grade inflammation (inflammaging), mitochondrial dysfunction, epigenetic drift, and impaired intercellular communication. Disruption of epidermal homeostasis appeared early in adulthood, likely driven by sustained inflammatory signalling. These data support the concept of cutaneous inflammaging, reflecting the skin’s constant environmental exposure, particularly to solar radiation.
Recent systems-level approaches will be presented demonstrating how they have been applied to better understand both dermal and epidermal skin biology. We investigated collagen proteostasis in the dermis to identify new skin care ingredient combinations. Whilst spatial transcriptomics and single-cell analyses, have revealed the impact of Galactomyces ferment filtrate and where these molecular interactions occur within the skin microenvironment.
By mapping these processes through a systems biology lens, we can begin to see how the Hallmarks of Skin Ageing reveal key biological targets that could be addressed to help maintain or restore skin longevity. These insights support the development of interventions that aim to improve skin health, resilience, and appearance for long-term consumer skin care benefits.
Biography
Michael joined Unilever in 1998 and has over 27 years’ experience in R&D with a particular focus on skin biology, scalp biology and the microbiome.
In 2005 Mike led the R&D programme for Lifebuoy bar and liquid reformulation including tracking how handwashing behaviour intervention reduces disease incidence in one of Unilever’s largest ever public health intervention study’s. 2008 saw a move to the Hair business with a pivot to scalp biology, antidandruff and the start of eight years working on scalp biology and dandruff. During this time Mike also led the establishment of the Shanghai bioscience team during a four year relocation to China.
Since returning to the Uk in 2016 Mike has helped to lead microbiome research for Beauty and Personal Care, delivering technology for Dove, Signal, PONDS and others, he has also contributed to the UK strategy on microbiome research, the Microbiome Innovation Centre at the University of Liverpool; the latest stage in a near 20year partnership between the University and Unilever in microbiome research. During his career Mike has authored over 28 publications on microbiome, skin biology and dandruff.
Presentation Outline
The skin microbiome colonises follicles and forms the outermost layer of skin, providing protective and nutritional benefits to the skin beneath. As we age, so our skin microbiome changes, the microbiome of infants is distinct from that of adolescents, which in turn is distinct from that of young adults, middle and older age. The trajectory of this change is reproducible across studies, with several publications reporting the successful use of skin microbiome data to predict chronological age. In addition to chronological aging, recent work has highlighted that physiological changes in premature aging and daily stress may also impact associated changes in the microbiome impacting both the taxonomic composition of the microbiome and the functional changes through which it might affect skin condition.
Dr Nükhet Cavusoglu
Head of High-Throughput Biology and Diagnostic platform
SPEAKER TOPIC
The science of biomarkers, when longevity becomes the new beauty quest and biological age the new metrics
Biography
Nükhet CAVUSOGLU joined l’Oreal Advanced Research more than 20 years ago. Currently she’s been leading the High-Throughput Biology and Diagnostic platform. She has received her pH.D from the University of Strasbourg, France, on developing mass spectrometry-based methods for the characterization of proteins. After a postdoctoral fellowship, she started her career in medical research on the physiopathology of retina at the Institute of Vision in Paris where she contributed to the discovery of new biomarkers in retinitis pigmentosa. In 2004 she decided to join l’Oreal R&I to develop MS-based approaches to the understanding of hair properties. After 6 years devoted to hair in close collaboration with academic laboratories, she deployed this know-how on skin, scalp and by integrating other –omics technologies such as genomics, metagenomics, metabolomics and lipidomics in her portfolio of techniques. Closely connected to biologists, her group focused on developing and applying these cutting-edge -Omics technologies to the discovery of new biomarkers characterizing skin and scalp conditions and transforming these discoveries into diagnostics for precision cosmetics.
Presentation Outline
The pursuit of beauty is evolving beyond the constraints of chronological age, entering a new era defined by longevity. This keynote addresses the pivotal transformation of our research, shifting from reactive “anti-aging” to a proactive “longevity beauty quest” focused on optimizing skin healthspan and resilience. In this context, biological age emerges as the critical new metric, more accurately reflecting the skin’s functional and molecular state far beyond chronological indicators. However, while the skin is our largest organ, biological clocks based on its unique biology have been relatively understudied, opening new avenues for research to develop more accurate skin aging predictors. This presentation will explore the power of biomarker science – measurable indicators that are revolutionizing our understanding. At L’Oréal, we have built decades of knowledge in skin biomarkers, from their identification to their use as effective biological clocks and tools for efficient, high-performing actives, paving the way for personalized, scientifically validated skincare solutions that truly optimize skin longevity.
Olivia Santoni
SPEAKER TOPIC
Understanding the regulatory landscape: Translating science in cosmetic product development into marketing claims
Biography
Olivia Santoni has an extensive knowledge of the cosmetics industry globally and over 20 ears of practical experience. She studied business law and healthcare product law before specialising in regulatory affairs.
She started her regulatory career working as a medical device regulatory inspector at the French Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). She then worked at the international department of the French cosmetics trade association (FEBEA) before moving to the UK and joining the UK Cosmetics Toiletry and Perfumery Association (CTPA).
Over the years, Olivia managed a regulatory and international team to deliver support and advice to companies as well as advocate for the interest of the UK and EU industry. She has led the UK Association’s work on Brexit and international regulatory affairs and has been an active participant at Cosmetics Europe groups on both regulatory and international issues.
In 2019, Olivia decided to found Bloom Regulatory Ltd to provide pragmatic and expert regulatory and strategic support to cosmetics companies in a world where business opportunities are growing but legislations are increasing and getting more and more complex.
Presentation Outline
The science of skin ageing and systems biology is evolving and creating new opportunities for scientists and industry. Launching new skincare products inspired by the latest scientific knowledge in this area will have to carefully navigate the regulatory requirements surrounding classification, claims compliance and substantiation. This presentation will provide an introduction to the regulatory framework and key considerations regarding claims on systems biology and skin ageing.
A future deeper understanding of systems biology, combined with thoughtful interpretation of regulatory guidelines in the US and UK/Europe, will not only ensure credible and compliant product claims but also shape the industry’s ability to lead innovation, build consumer trust, and set the standard for next-generation skincare enhancing skin health and wellbeing.
Biography
Paul joined Procter & Gamble (P&G) in 1988 as a PhD Microbial biochemist and spent the majority of his career leading various aspects of Skin Research, working across most of the Company’s Operating Units (as he maintains that all of them touch the human skin in some way!). He retired from P&G in 2024.
He is a Visiting Professor to the London College of Fashion and past Visiting Professor to the UCL School of Pharmacy. He is a past Chair of the Cosmetics Europe (CE) Sun Protection Methods Task Force, the standardIsation of SPF and UVA methods.
In his spare time, he re-applies his skin biology expertise to resource-poor settings and, in 2012, co-founded an NGO in Ethiopia to help the 1.5+ million sufferers of Podoconiosis (non-filarial, lower-leg lymphoedema).
He is married to Ali, has 3 grown-up children and is recently a grandfather! He loves the outdoors… running, mountains, scuba-diving and, in 2013, bought an old, run-down property on the Isle of Mull which he thinks is a small piece of Heaven.
Presentation Outline
To be confirmed.
Professor Rachel Watson
Executive Director
SPEAKER TOPIC
The skin: A window of opportunity for healthy ageing?
Biography
Rachel Watson was Professor of Cutaneous Science at the University of Manchester (UK), prior to her appointment as Executive Director of both the A*STAR Skin Research Labs and the Skin Research Institute of Singapore in 2023. She received her BSc (Anatomy & Cell Biology) and PhD degrees from the University of Sheffield, UK.
Passionate about geroscience, Rachel’s research includes understanding the mechanisms which lead to skin ageing (both intrinsic and that augmented by the environment) and the assessment of extracellular matrix repair, particularly by topical retinoids.
Presentation Outline
After decades of cutaneous research – often focused on the ‘favourite’ pathways of the individual researcher – we now appreciate the exquisite complexity of skin and how its biology changes as we age. Our environment – and our conduct in it – impacts skin health greatly, the exposome influencing multiple pathways to alter skin behaviour, appearance and disease prevalence. Arguably the body’s largest organ, the opportunity for the skin to affect systemic health is now becoming apparent; physiological processes associated with skin ageing influence, and are influenced by, systemic ageing processes. This provides us, as researchers, with unprecedented opportunities to modulate skin health to influence – and potentially improve – systemic health, and vice versa. We cannot study skin in isolation; instead, we must adopt a holistic approach to our research, to better serve patients and consumers in the quest for both skin and systemic health.