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Folate deficiency prevalence is high among individuals aged ≥65 years, mainly due to reduced dietary intake and intestinal malabsorption. Folate deficiency may contribute to impaired cognitive function and nerve signaling in the brain, potentially increasing the risk of mild cognitive impairment and dementia. Supplementation with Quatrefolic® active folate may restore plasma folate levels and counteract the various physiological changes that cause deficits in cognitive performance and neurological functioning.